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KMID : 0389420100180040305
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Korean Journal of Stress Research
2010 Volume.18 No. 4 p.305 ~ p.314
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Protective Effect of Codonopsis pilosula (Franch) Nannf on Intracerebral Hemorrhage-Induced Memory Deficit and Apoptotic Neuronal Cell Death in Rats
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Kim Dea-Young
Ko II-Gyu
Kim Bo-Kyun
Kim Sung-Eun
Lee Shin-Ho
Jin Young-Ho
Kim Dong-Hee
Kim Chang-Ju
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Abstract
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Intracerebral hemorrhage (ICH) is a common cause of stroke, and it occurs mainly in the striatum, thalamus, cerebellum, and pons. Codonopsis pilosula (Franch) Nannf (Dangshen) is the roots of a perennial herb, the same family as ginseng. It comprises a rich resource of neuroactive compounds, and they are potential signaling molecules. In the present study, we investigated the effects of the Codonopsis pilosula intrastriatal on hemorrhage-induced memory deficit and apoptotic neuronal cell death in rats. ICH in the striatum was induced by injection of collagenase using strereotaxic instrument. The rats in the Codonopsis pilosula treated groups received Codonopsis pilosula orally once a day for 14 consecutive days, starting one day after surgery. For this study, step-down avoidance task, radial 8-arm maze task, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining, immunohistochemistry for caspase-3, Western blot for Bax and Bcl-2 were performed. The present results showed that cognitive incapacity by ICH was associated with the increase of apoptosis in the striatum. Codonopsis pilosula treatment alleviated the ICH-induced impairment of spatial learning ability and short-term memory by suppressing neuronal apoptosis in the striatum. Here in this study, we suggest that Codonopsis pilosula is effective for the recovery after ICH insult.
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KEYWORD
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Intracerebral hemorrhage, Codonopsis pilosula, Apoptosis, Spatial learning ability, Short-term memory
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